Dina Rodinskaia, Crystal Radinski and Jake Labuhn
Background: Progressive deterioration of synaptic plasticity and synaptic connectivity between neurons is a neurophysiological hallmark of brain ageing and has been linked to the severity of dementia. We hypothesized that electroencephalographic evidence of the disruption of functional connectivity might be used to diagnose Alzheimer's dementia. Improving the accuracy and reducing the time needed to diagnose AD could allow timely interventions, treatments, and care cost reduction. In our previous study, we identified four promising markers. Temporal Gamma EEG coherence marker (TG_marker) was selected for evaluation.
Methods: This blinded diagnostic test accuracy study examined diagnostic parameters for TG_marker in individuals with AD, vascular dementia, Parkinson's, depression and healthy controls. The TG_marker sensitivity, specificity, PPV, NPV, and positive and negative likelihood ratio were evaluated.
Results: TG_marker demonstrated high sensitivity (>89%) and specificity (95%) in all neurodegenerative groups with high PPV (>92%) and NPV (>93%).
Conclusion: TG_marker could be a valuable tool in detecting neurodegenerative process in the brain and excluding dementia in TG_marker negative patients. More testing is needed to understand the role of neurodegeneration in pseudo-dementia and age related brain changes.
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