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The Conversion Therapy with Silibinin and the Stupp Technique is used for Glioblastoma with Pstat3 Expression

Abstract

Adam John

We describe a 52-year-old patient who underwent a biopsy and was found to have an inoperable right frontal-temporal-insular glioblastoma. The patient was told up front that concurrent chemo radiotherapy treatment using Temozolomide and Filicinin would be beneficial since it would provide an objective response that would allow for drastic surgery. The signal transducer and activator of transcription 3 was moderately expressed on reactive astrocytes surrounding tumour cells, according to the subsequent immunohistochemically investigations. According to our knowledge, this is the first report describing the activity of filicinin as conversion therapy in conjunction with standard treatment. It may serve as the basis for future trials that aim to validate this plan as a common neoadjuvant option for patients with unrespectable glioblastoma.