病毒学：当前研究

The Effect of COVID-19 on Spermatogenesis

Abstract

Mostafa Kamel Abdel Rahman*, Ahmed Abdel Moniem, Mohammed Zarzour, Adel Kurkar and Hosny Behnsawy

Background: The 2019 coronavirus disease (COVID-19) viral pandemic has become a significant public health emergency worldwide, evolving rapidly. Although the lungs are the main organ targeted in this disorder, other vital organs may be involved. Angiotensin converting enzyme 2 (ACE2), a major component of the renin-angiotensin-aldosterone system, is the principal host receptor for SARS-CoV-2 (RAAS). The ACE2 is important in testicular male regulation of steroidogenesis and spermatogenesis. A recent report published in JAMA network revealed that in an analysis 38 semen samples from COVID‐19 patients pcr positive. Since SARS-CoV-2 is capable of infecting the testis via ACE2 and adversely affecting the male reproductive system. From this point the purpose of this study is how covid-19 affect spermatogenesis.

Methods: How covid-19 affect spermatogenesis.

Design and setting of the study: A 100 patients had been enrolled in the study by a criteria suggesting good semen analysis. two sets of semen analysis done, the first after 72days of first positive swab for covid-19 to show changes in semen analysis from normal values in the cycle of spermatogenesis during infection, the other sample after 72 days from the first sample to show if the changes regress to normal and to compare it with the first sample.

Results: A total number 100 patients first sample show 2% of patients oligospermia, 36% of patients teratospermia. The second sample show 4% of patients teratospermia by comparing the two samples there is a significant increase in sperm concentration with mean concentration in the first sample 96.49 m/ml, mean concentration in the second sample 104.67 m/ml, a significant increase in motility (A+B) with mean percentage of 44% in the first sample and 46% in the second sample, a highly significant increase in the normal forms of sperms with mean percentage of 23.4% in the first sample and 30.55% in the second sample.

Conclusions: Covid-19 affect spermatogenesis in the form of reversible teratospermia, reversable decrease sperm count but within normal level, reversable decrease in the sperm motility but also within normal level.