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The Effect of Smoke Combined with the Multicancer Marker, Rs6983267, Located at Region 3 of Chromosome 8q24 in Prostate Cancer Patients

Abstract

Amalia Papanikolopoulou, Olfert Landt, Martin Reczko, Konstantinos Ntoumas, Stefanos Bolomitis, Stavros I Tyritzis, Constantinos Konstantinides and Nikolaos Drakoulis

Introduction: Common variants on human chromosome 8q24 were found to be associated with prostate cancer risk with different frequency and incidence among the investigated populations. We examined the effect of smoke on this type of cancer and its relationship with the risk variant rs6983267, located at region 3 of chromosome 8q24, in a prostate cancer case-control study conducted in the Greek population in light, intermediate and heavy smokers.

Materials and methods: Samples of total blood from 74 patients with histologically confirmed prostate cancer and 24 healthy individuals were genotyped using real time polymerase chain reaction (PCR). Tumor-node-metastasis (TNM) stage, Gleason score and levels of prostate-specific antigen (PSA) at diagnosis were included in the analysis.

Results: Light (Packyears, PY<10) and heavy (PY>30) smokers are positive associated with prostate cancer, with an additive risk for the carriers of rs6983267 with positive smoking history (ORadj=21.36, C.L=3.79-120.39) to develop the disease.

Conclusions: The SNP, rs6983267, has an independent risk for carriers to develop prostate cancer and in combination with smoke; it confers additive risk for the disease, similarly to others, well established risk factors such as age, family history and ethnicity.