Jacques Meng*
Caspase recruitment domain-containing protein 9 is a crucial component of innate immune responses, particularly in orchestrating inflammatory reactions and shaping adaptive immunity. Its significance spans across various infections, where it modulates cell- and organ-specific immune responses. This article explores the multifaceted role of CARD9 in different infections, elucidating its involvement in pathogen recognition, activation of immune cells, and regulation of inflammatory pathways. Additionally, it delves into how CARD9 influences the immune response in specific cell types and organs, shedding light on its potential as a therapeutic target for infectious diseases. CARD9, a key adaptor protein, is involved in various cellular processes, including inflammation, autophagy, and cytokine production, making it a crucial player in the host defense against infections. In this review, we delve into the multifaceted roles of CARD9 in cell and organ-specific immune responses across different infections.
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