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Thick Blood Smear vs. qPCR Diagnostic Accuracy for Malaria Associated with Pregnancy in Colombia

Abstract

Carmona Fonseca*

This study aimed to evaluate the accuracy of the Thick Blood Smear (TBS) versus quantitative Polymerase Chain Reaction (qPCR) for the diagnosis of Malaria Associated With Pregnancy (MAP) caused by P. falciparum or P. vivax in Colombia in its Gestational Malaria (GM), Placental Malaria (PM) and Congenital Malaria (CM) forms as well as to compare its accuracy in different subgroups of pregnant women according to the presence of fever, anaemia and a history of malaria. 829 pregnant women, 579 placentas, 381 samples of the umbilical cord and 221 samples of newborn peripheral blood were evaluated for this diagnostic study. Sensitivity, specificity, predictive values, likelihood ratios and validity index, together with their 95% confidence intervals, were used to evaluate accuracy.

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