药物化学

Trichoderlates A and B, Two Bioactive Metal Complexes of Hydroxyaspergillic Acid from the Marine-derived Fungus Trichoderma erinaceum F1-1

Abstract

Yong-Wei Guo, Yi Qiu, Hou-Jin Li, Zi-Bin Jiang, Ming-Jun Hong, Qiong-Bo Huang, De-Po Yang, and Wen-Jian Lan

Two new metal complexes of hydroxyaspergillic acid, trichoderlates A (1) and B (2), and five previously reported compounds (3-7) were obtained from Trichoderma erinaceum F1-1. The structures of new compounds were determined by their NMR, HRMS data, optical rotation calculations and chemical methods. This is the first report about metal complexes of hydroxyaspergillic acid from the genus Trichoderma. Trichoderlates A (1) and B (2) exhibited significant cytotoxicities against MDA-MB-435 human melanocyte cancer cells with IC₅₀ values of 3.3 and 9.5 μM, respectively. Trichoderlate A (1) also showed significant cytotoxic activity against A549 adenocarcinomic human alveolar basal epithelial cells with IC₅₀ value of 6.1 μM.