疟疾控制和消除

Using Human Brain Organoids Model for Cerebral Malaria

Abstract

Gouri Sankar

In cerebral malaria patients, neurologic injuries are a significant cause of morbidity and mortality. However, there is a dearth of a comprehensive approach to this problem, so we propose an in vitro system for cellular approaches to human cerebral malaria research. Our primary objective was to develop a cellular system for the purpose of determining the molecular changes in human brain vasculature cells that are analogous to the blood–brain barrier (BBB) in cerebral malaria (CM). We identified specific gene expression profiles in Plasmodium falciparum-activated human brain microvascular endothelial cells (HBMEC) through transcriptomic analysis. In addition, we propose potential brand-new genes connected to parasitic activation.