癌症科学与治疗

使用雄激素受体表达作为预测转移性三阴性乳腺癌女性生存期的新型潜在生物标志物

Abstract

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??????????? (AR) ??????????????????????????????????????????????????????????????????????????????? (TNBC) ??????????? AR ??????? TNBC ???????????????????? AR ?????? TNBC ???????

??????????? IV ? TNBC????????? (ECOG>2) ????????? >10% ?????? AR ????????????????

???? 208 ? TNBC ?????????? 24 ??? TNBC?24 ?????33% ? AR ???????????? 61 ???? 30-78 ??????????????????????????? (mPFS) ????? (OS) ??? 3.5 ????? 0.3-27.3 ???? 25.9 ????? 2.52-122.2 ????????????AR ????? TNBC ? PFS?3.2 vs 7.9 ???p=0.02?HR=2.57?95% CI 1.15-10.53?? OS?20.5 vs 47.4 ???p=0.01?HR=2.88?95% CI 1.32- 9.43??????????????AR ??? PFS ????????p=0.04?HR=2.19?95% CI 1.52-5.91???? OS ????????p=0.05?HR=2.21?95% CI 0.98-2.55??

?????????????AR ????????????????????????????????????????????? TNBC ?? AR????????? TNBC ????????????