Amber Valerie*
As a consequence, patients with vasculitis are at an increased risk of cardiovascular complications, including coronary artery disease, myocardial infarction, stroke, and peripheral artery disease. Several mechanisms contribute to the heightened cardiovascular risk in vasculitis patients. Chronic inflammation, a hallmark of vasculitis, plays a crucial role in the development and progression of atherosclerosis, the main underlying cause of cardiovascular complications. Inflammation leads to increased endothelial permeability, adhesion molecule expression, and recruitment of immune cells, initiating the formation of atherosclerotic plaques. Additionally, vasculitis-associated vasculopathy and vasospasms can further compromise blood flow and promote thrombotic events. Immunosuppressive therapies, such as glucocorticoids and immunomodulatory agents, are commonly used to achieve disease remission and prevent vascular damage. Tight disease control, regular monitoring of disease activity and early intervention can help minimize the impact of vasculitis on the cardiovascular system.
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