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体积 7, 问题 3 (2021)

2020 年奖项

3rd World Summit on Virology, Vaccines & Emerging Diseases

Giulio Tarro

The Award tries to perceive works of qualification and is given for recognized and extraordinary accomplishments in all fields of disciplines. Awards are don't just recognize achievement; they perceive numerous different characteristics: capacity , battle, exertion and, most importantly , greatness and hard work.
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Antiseptic Action of E-101 Solution, a Myeloperoxidase-Mediated Formulation, in the Presence of Whole Blood Compared to Conventional Wound Antiseptics and Biocides

Gerald A. Denys*, Jessica L. Carpenter, Robert C. Allen and Jackson T. Stephens Jr

E-101 solution is a first-in-class myeloperoxidase containing antimicrobial solution developed for topical application. The active ingredients in E-101 solution are two enzymes, porcine myeloperoxidase (pMPO) and glucose oxidase (GO) in an aqueous solution and activated by the addition of a glucose solution. Once activated, the reactive species hydrogen peroxide, hypochlorous acid/hypochlorite (HOCl/OCl-), and singlet oxygen (1O2) are generated. We evaluated the effect of whole human blood on the performance of E-101 solution compared to commercially available wound antiseptics and commonly used biocides. The wound cleansers NeutroPhase, Microcyn, and Vashe with the active HOCl/OCl- component were tested according to the USP-51 effectiveness test in the presence of 0, 1, 2 and 5% blood. Comparative time-kill studies against chlorhexidine, povidone-iodine, sodium oxychlorosene were tested in the presence of 0, 2, 5 10, and 20% blood. In the USP-51 test, E-101 solution demonstrated >2 log10 reduction against bacterial and fungal isolates in the presence of 5% blood at days 14 and 28. With the exception of NeutroPhase activity against S. aureus, all comparable wound antiseptics demonstrated <2 log10 reduction in the presence of 5% blood at days 14 and 28. Time-kill microbicidal data observed in the presence of blood demonstrated that E-101 solution was the most active biocide, followed by chlorhexidine and povidone-iodine. The presence of 2% blood completely inhibited the activity of sodium oxychlorosene. In summary, E-101 solution remained active in the presence of blood containing catalase and other substances that competitively react with 1O2 and HOCl/OCl- as a safe and effective wound antiseptic

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