?????????????????????????????
???????????????? (CHC) ????? IFN ?????????????? I ???? (IFN) ?? α-2 (IFNAR-2) ?????????????????????????? IFNAR-2 ??????????????? (SVR) ??????
?????????????????????????????
??/????????28B (IL-28B) ??????????????????(PEG-IFN) ?????(RBV) ?????????(CHC) ??????????(SVR) ????????????????????? (Mo) 1 ?????? 2 (IFNAR-2) ???????? IL-28B ????????????
??????? 148 ??? PEG-IFN ? RBV ?????? 1b ?????? CHC ????????????? IFNAR-2 ??? Mo ???????????? 28 ???????? (MFI)? 148 ????? 83 ??????????rs8099917 ?? IL-28B ??????
??? rs8099917???TT??????SVR??SVR?????Mo MFI?????????????7???14???SVR??????Mo MFI????rs8099917???TG??SVR???
??? IFNAR-2 ??? PEG-IFN ? RBV ? IL-28B ??????? CHC ????????
Venkatachalapathy TS ? Subhashish Das
??????????????????????????????????????????????????????????????????????????????????????????????????????2011?11??2012?1?3???????????1694???????????796????920?????1694???? 124 ??????????????? 208 ???? 588 ?? ???????? 456 ????????? 354 ??3 ????????? 110 ?? 222 ????? >10 gms%???????330 ????? 7.1-9.9 gms%?250 ????? <7 gms%? 100 ??????????????? 369 ???????451 ????????? 136 ???????????? 660??????2??2?????????? 3 ?????????????? 20.3 ?????? IP ? OP ???? 26.4 ???? IP ???? 18.4 ??/???????? 450 ?????735 ????????????????????????????????????????????????????????????????????????????
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