生物医学与药物科学杂志

Coenzyme Q10 (CoQ10) antioxidant strength has been seen in many studies. Most chemotherapy have been seen to cause side effect through oxidative stress. This work seeks to study the ability of CoQ10 to counter the oxidative stress and thus remediate the chemotherapy induced toxicities of chemotherapeutic agents.

Fifty male mice were used for this study. They were divided into 5 groups (of 10 rats each) which include normal control (standard diet plus intraperitoneal (i.p) normal saline), 5 Fluorouracil (5FU) control (negative control) (standard diet plus i,p 5 fluorouracil at 200 mg/kg body weight) and three treatment groups of CoQ10 incorporated into standard diet at 100 mg/kg, 200 mg/kg and 400 mg/kg of feed of feed. The weight of the rats was measured every 3 days and recorded. The experiment lasted for two weeks after which the rats were euthanized by cervical dislocation. Blood was collected for red blood cell indices (PCV, MCV, MCH, Hemoglobin, MCHC) and white blood cell parameters (WBC, NC, LC and Platelet count) hematological study and the spleen fixed in 10% formalin for histological study.

The weight did not show any significant difference all groups compared to the control while the red blood cell indices showed a significant decrease (p<0.001) in the negative control group when compared to the positive control group except MCHC which showed no significant difference (p>0.001). The treatment groups showed an increase in all parameters when compared to the negative control except MCHC.

The white blood cell parameters all showed increase except for the Lymphocyte Count (LC). The histological slide showed the damage by 5- FU as seen in the negative control group while the treatments ameliorated it in the treatment group. The result showed the cytotoxic effect of 5-FU on the cells and the amelioration by the COQ10.