美容与毛发学杂志

The differential diagnosis of a lobular panniculitis without vasculitis can be extensive. This review article is based on a case we recently described and is aimed to address the most common variants of lobular panniculitis that could be mistaken for Subcutaneous Panniculitis-Like T-cell Lymphoma (SPTCL). The neoplastic lymphocytes express CD8+ with rearranged an α/β subunit of the T-cell receptor. Cytotoxic markers are always expressed (TIA1, perforin, and granzyme B), but CD56 and CD30 are consistently negative

Objective: Topical application of minoxidil has been adopted as an effective treatment for male and female pattern hair loss. While higher concentration formulas exhibit better efficacy, dissolving and stabilizing minoxidil is technically challenging. L-(+)-Tartaric Acid (LTA) is a colorless crystalline dicarboxylic acid found in plants and has been used as an additive in various hair care products to stabilize the biological functions of active ingredients. LTA has been added to minoxidil to maintain the quality of over-the-counter formula. To date, the influence of LTA on human Hair Follicle (HF) cells has not been sufficiently investigated. As the Dermal Papilla (DP) plays pivotal roles in the regulation of HF regeneration and the hair cycle, we aimed to elucidate the effects of LTA on human Dermal Papilla cells (hDPCs). Methods: hDPCs were first subject to cytotoxicity and alkaline phosphatase assay after treated LTA. Microarray comparison analysis was performed to elucidate LTA effects on global gene expression on LTA-treated and non-treated hDPCs. Subsequent real-time polymerase chain reaction analysis using multiple donor-derived hDPCs was done to further confirm LTA-induced hair growth genes up-regulation. Results: LTA exhibited no influence on hDPCs in a cytotoxicity assay. The activity of a representative hDPC marker enzyme, alkaline phosphatase, was not impaired by LTA in cultured hDPCs. Microarray comparison analysis of LTA-treated and non-treated hDPCs elucidated that LTA minimally affected the molecular signature of hDPCs but, intriguingly, up-regulated some hair growth-related genes. Subsequent real-time polymerase chain reaction analysis using multiple donor-derived hDPCs confirmed that LTA indeed increased the gene expression of activin A receptor type 2A (ACVR2A) and Insulin-like Growth Factor Binding Protein 5 (IGFBP5), while down-regulation of hair growth-related genes by LTA was inconsistent among hDPCs derived from respective donors. Conclusion: These results suggest that LTA minimally affects but potentially supports the biological characteristics of hDPCs. LTA may represent a useful additive to generate efficacious, high concentration formula of active reagents, represented by minoxidil.

Congenital melanocytic nevi with a diameter of at least 10 cm or covering 1% body surface area on the face/head/neck or 2% on rest of the body at any age, and by an extetension those least 6 cm on the trunk and 9 cm on the head in a neonate are known as giant congenital melanocytic nevus (GMNC). Although, a rare entity they may pose possible risk of malignancy and neurocutaneous melanosis, apart from cosmetic concerns. The psychosocial distress posed by them has also been studied extensively by many authors. On histopathological analysis epitheloid lymphocytoid and neuroid nevus cells can be visualized. Owing to such myrid presentations the management option for GCMN has to be tailored to every patient. There is a common consensus that prophylactic removal of a GCMN has little to no advantage. The partial debulking of a GCMN can be done by mechanical or chemical exfoliation, currete, shave excision or laser therapy. However, in view of potential risk of malignancy total or subtotal deep excision followed by plastic reconstruction must be considered, especially in cases involving the head and neck area.

The article deals with the use of platelet-rich plasma in the treatment of androgenetic alopecia: effectiveness, problems and prospects. Androgenetic Alopecia (AGA) is one of the most common types of non-scarring hair loss. Baldness affects the psycho-emotional state of a person, which significantly reduces the quality of life. An opinion deviating from generally accepted standards exists that with a normal level of androgens in the blood, AGA in men is a normal biological phenomenon, and not a disease. Regardless of how their condition is classified, people with AGA perceive it as a deviation from the norm, unacceptable from a psychosocial point of view, and turn to a doctor for treatment.

Plexr is the latest technology for Blepharoplasty and Non Invasive Eye Lid Surgery. Limited studies have been done on this technique and so far no side effects have been reported. For the first time in this study, we will describe 3 patients with complaints after Plasma Exeresis (Plexr). Here the authors present 3 patients that presented to the authors institution over a 5-month period with complaints after Plasma Exeresis (Plexr). Complaints included upper lid skin burns, severe eyelid swelling and erythema, and Postinflammatory hyperhypopigmentation eyelid lesion and unhealing dermatochalasia. In this report we discuss the clinical presentations, diagnostic evaluation, treatment options, and clinical outcomes as they relate to Complications of Noninvasive Upper Lid Blepharoplasty (Plasma Exeresis (Plexr)).