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体积 13, 问题 11 (2022)

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SOX Transcription Factors Control Cervical Cancer Development: Uncovering Therapeutic Strategies and Signaling Networks

Gerald Devault

Cervical disease is the fourth normal gynaecologic malignant growth and is considered as second driving reason for death among ladies. Different procedures are applied in therapy of cervical malignant growth including radiotherapy, chemotherapy and medical procedure. Be that as it may, cervical disease cells show forceful conduct in cutting edge stages, requiring novel methodologies in their disposal. Then again, SOX proteins are record factors equipped for directing different sub-atomic pathways and their demeanour shifts during embryogenesis, infection improvement and carcinogenesis. In the current audit, our point is to uncover job of SOX record factors in cervical disease. SOX record factors play like a blade that cuts both ways in malignant growth. For example, SOX9 has both growth silencer and cancer advancing job in cervical disease. Hence, definite job of each SOX individual in cervical malignant growth has been examined to coordinate further analyses for uncovering different capabilities. SOX proteins can manage multiplication and metastasis of cervical malignant growth cells. Moreover, reaction of cervical malignant growth cells to chemotherapy and radiotherapy is firmly controlled by SOX record factors. Different downstream focuses of SOX proteins, for example, Wnt flagging, EMT and Hedgehog have been recognized. Furthermore, upstream arbiters, for example, microRNAs, lncRNAs and circRNAs can manage SOX articulation in cervical malignant growth.

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Percutaneous Anthropometric Dimensions of the Upper Arm and Forearm Bones: Determination of Sex and Stature in Adult Nigerian Population in Lagos

Robert Smithwick

Background: Stature, like other phenotypic characteristics, is a crucial identification indicator that is influenced by both genetic and environmental factors. One of the most important and useful anthropometric parameters that determine a person's physical identity is stature, or body height. This is because of the alarming rise in the frequency of road, flood, intentional mutilation, and natural disasters. In forensic medical examination or anthropological studies, it is also regarded as one of the important and significant parameters for establishing personal identity.

Objectives: To measure the percutaneous length of the arm and forearm bones in an adult Nigerian population to determine stature and gender.

Methods: The sample group for this study consisted of 222 people between the ages of 18 and 65, split evenly between 115 men and 107 women. The workers, students, and volunteers at the University of Lagos made up the sample group. a wide range of anthropological instruments, including the Stadiometer, an anthropometric instrument made in Germany by SECA alpha®. A centimetre-calibrated calliper, weighing balance, and tape were used for the measurement.

Conclusion and Findings: When logistic regression was used to make a sex prediction, the intercondylar breadth had the highest value for statistical significance. The ulnar measurement had the strongest correlation with stature, while the intercondylar measurement had the weakest correlation across all parameters. Percutaneous measurement of arm and forearm lengths is available for both men and women, and it is reliable for estimating stature and determining sex. There is a stronger correlation between sexual dimorphism and the intercondylar. Straightforward and various direct relapses exhibited that utilizing the foot length is the most dependable procedure to anticipate and appraise height.

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