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In contrast to Native Valve Endocarditis (NVE), prosthetic valve endocarditis (PVE) is a rare and serious complication of valve replacement that is associated with a high rate of morbidity and mortality. There are two main problems: figuring out what PVE is and how to treat it The diagnosis of PVE is challenging and frequently requires a variety of imaging methods in addition to standard microbiological tests. Although Computed Tomography (CT) and 18F-fluodeoxyglucose positron emission tomography/CT are frequently required, Transesophageal Echocardiography (TEE) remains the most common imaging tool for PVE diagnosis.