组织科学与工程学报

Tissue chips, also known as organs-on-chips or microphysiological systems, are innovative platforms that mimic the structure and function of human organs in a miniature form. They provide a powerful tool for studying human physiology, disease mechanisms, drug development, and personalized medicine. This article aims to provide an in-depth exploration of tissue chips, including their development, applications, advantages, challenges, and future prospects.

Tissue engineering is an interdisciplinary field that aims to create functional biological tissues and organs through the integration of cells, biomaterials, and biochemical factors. Among these components, biomaterials play a critical role in providing structural support, guiding cell behavior, and facilitating tissue regeneration. This article provides a comprehensive overview of bio materials used in tissue engineering, focusing on their properties, fabrication techniques, and applications. It also highlights recent advancements and future prospects in the field.

Adipose tissue, comprising white adipose tissue (WAT) and brown adipose tissue (BAT), is a specialized connective tissue that serves essential functions in the human body. It acts as a site for energy storage, insulation, and endocrine regulation. This comprehensive review explores the structure, function, and metabolic significance of adipose tissue. It discusses the roles of WAT and BAT, including their respective contributions to energy storage and thermogenesis. The review highlights the endocrine regulation of adipose tissue, focusing on the secretion of adipokines and their implications for metabolic health. Furthermore, it discusses the metabolic significance of adipose tissue in relation to obesity, insulin resistance, and lipid metabolism. The regulation of adipose tissue by genetic, environmental, and hormonal factors is also examined. Finally, the therapeutic implications of understanding adipose tissue biology are explored, with a focus on potential targets for the treatment of obesity and metabolic disorders. A comprehensive understanding of adipose tissue is crucial for addressing the global health challenges associated with metabolic dysregulation.