Rahul Parashar, Sanjiv K Verma and Sohaib Ahmad
Background: Gallbladder cancer (GBC) is the fifth most common cancer of the gastrointestinal tract (GIT) and one of the most common cancers of the extra hepatic biliary tract with a high rate of mortality. There is no specific clinical presentation of early stage GBC and thus preoperative diagnosis is difficult in many. Chronic inflammation, infection and gallstones are the factors leading to malignant transformation of gallbladder epithelium (GB). The early diagnosis of GBC is not possible in all and in many the disease is diagnosed at an advanced stage.
Methods: The present study was an observational study done with the aim of studying the clinical and hepatic parameters in patients diagnosed with carcinoma gall bladder. Study was conducted on 72 patients who were diagnosed and staged according to AJCC staging criteria. The clinical profile and liver function tests were noted.
Results: The maximum number of cases (n=24; 33.3%) were in the age range of 41-50 years and in a ratio of M:F- 1:3. About 40.2% of patients presented had increased serum bilirubin levels, more than 50% of patients had deranged liver enzymes (SGOT, SGPT), levels of albumin were below normal in 62.5% cases and 66.6% of had elevated ALP levels. The presence of gall stones on ultrasonography was seen in 79.2% (n=57) of patients.
Conclusion: Liver function derangement is common in patients of carcinoma gall bladder in early as well as late stages and the dysfunction can be due to malignancy or the other diseases affecting liver.
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