生药学与天然产物杂志

Biosynthesis of medicinally important plant metabolites by unusual type III polyketide synthases

Abstract

Osague Ehioze

Recent analysis progress on the “second generation” sort III polyketide synthases is summarized. This category of enzymes catalyzes uncommon condensation chemistries of CoA thioesters to come up with numerous core structures of medicinally vital plant secondary metabolites, as well as the R1–C–R2 scaffold of group quinolones, curcuminoids, yet because the 8-azabicyclo octane ring of tropane alkaloids. The invention of this fascinating catalyst taxonomic category provides glorious opportunities for the manipulation of the catalyst reactions to expand the availability of natural and unnatural molecules for future drug development. The type III polyketide synthase (PKS) taxonomic category enzymes generate unbelievably numerous core structures of medicinally vital plant secondary metabolites, as well as flavonoids, stilbenes, chromones, pyrones, phloroglucinols, resorcinols, xanthones, acridones, and quinolones . For instance, chalcone synthase (CHS) and stilbene synthase (STS) are plant-specific typical sort III PKSs that settle for p-coumaroyl-CoA because the starter substrate to catalyse 3 sequent condensations with malonyl-CoA to come up with naringenin chalcone and resveratrol, severally.