移植技术与研究

Correlations between Post-Transplant Delirium and Clinical and Neuroimaging Data

Abstract

Brian Anderson

Adults following hematopoietic stem cell transplantation (HCT) frequently experience delirium; however, the clinical and neuroimaging correlates of post-HCT delirium have not been clearly defined. Therefore, using a retrospective cohort of 115 persons who underwent neuroimaging following allogeneic HCT, we investigated the prevalence of delirium and neuroimaging correlates of post-transplant delirium. Using previously approved techniques for the retrospective detection of post-procedural delirium assessed on the chart, delirium was determined. A multidisciplinary team with experience in HCT, psychiatry, and psychology independently reviewed the medical records of consecutive allogeneic HCT patients who had neuroimaging evaluations and transplantation at a single location between January 2009 and December 2016. Also noted were white matter damage and brain volume decrease neuroimaging indicators.