Olukayode Solomon Ajayi, Olaoye Solomon Balogun and Folasade Agnes Ajinuhi
In this study, the crude, defatted extracts and the pure isolated xanthone (1,8-dihydroxy-2,5-dimethoxyxanthone) were screened in vitro for cytotoxicity activities, the xanthone was isolated from the defatted fraction of the aqueous methanolic stem-bark extract. The cytotoxic activity was evaluated using the brine shrimp lethality test of stem bark extract and the isolated compound, 1,8-dihydroxy-2,5-dimethoxyxanthone gave LC50 values less than 200 μg/mL, indicating a high pharmacological potential and could serve as anticancer agent.
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