生物传感器与生物电子学

Nano-sphere lithography fabrication of large-area ordered arrays plasmonic nanostructures for high-sensitivity biosensors

Abstract

Roberto Rella

In this work, highly ordered array of plasmonic nanostructures have been fabricated developing a simple and reproducible approach based on nano-sphere lithography (NSL). This cost-effective method is based on the self-assembling of close-packed polystyrene (PS) particles at air/water interface, and enables the fabrication of colloidal mask characterized by a high quality crystal structure. Periodic array of metal nanostructures can be easily prepared on large-area by exploiting the interstitial geometry of this cheap lithographic mask. In particular, highly ordered array of gold nano-triangles distributed in hexagonal lattice have been fabricated on different kind of substrates. In this work, an optical biosensor based on localized surface plasmon resonance has been developed for the sensitive detection of lipopolysaccharides (LPS).