生物分析与生物医学杂志

Relation between LDH and Mg as Factors of Interest in the Monitoring and Prognoses of Cancer

Abstract

Aurelian Udristioiu, Sorina Comisel, Cristina Popescu and Manole Cojocaru

The aim of this work was to evaluate the correlation between the serum levels of lactate dehydrogenase (LDH) and magnesium (Mg) alone or in report Ca/Mg, among patients with diagnosed malignant diseases who were admitted to the oncology department of a county hospital.

Results:Among the patients in this study, 55 patients (73%) exhibited normal serum levels of Mg (normal range value = 1.60-2.3 mg/dL; mean value = 2.2 mg/dL; SD = 0.2; p = 0.02), normal values for Ca (range 9.1 -10.8 mg/100 m, mean value = 9.90, SD = 2.5, P = 0.05) and normal report Ca/Mg (range 4.5-7), following cancer therapy with good results, in the stage of remission tumor.

A number of 12 patients (16%), which was discovered in onset of cancer diseases, displayed high levels of serum Mg (range =2.6-3.27 mg/dL; mean value = 2.89 mg/dL), high values of Ca, (mean value = 11.2 mg/dl), and low values of report Ca/Mg ( range = 1.7- 3.8).

Six patients (8%), with bad prognostic, unfavorable cancer therapy and frequent relapses, exhibited low levels of Mg (range = 0.60-1.50 mg/dl; mean value = 1.05 mg/dL), low values of Ca (8.2-8.8 mg/dl) but high report Ca/Mg (range = 8.3-23.5). High Ca/Mg ratio was also significantly associated with high-grade cancer.

The levels of serum lactic dehydrogenase (LDH) were also evaluated in patients newly diagnosed with cancer and in patients with unfavorable responses to the cancer therapy (range = 240-1330 U/L; mean value = 787 U/L; SD =1.33; p = 0.002; normal values 135-225 U/L).

Conclusion: The total serum LDH, Mg and report Ca/Mg levels can be used as markers for the onset of malignant diseases and for monitoring the response to cancer therapy.