生物陶瓷的开发与应用

Synthesis and Characterization of Cowry and Crab Shells Based Chitosan for Drug Delivery

Abstract

Akinwole IE, Alebiowu G, Oyatogun GM, Abere DV, Oluwasegun KM, Oyatogun AO, Abioye AA, Abioye OP, Adenigba AE, Ayodele TJ

This work aims to synthesize chitosan from locally available cowry and crab shells for Pharmaceutical application in drug delivery. Chitosan was synthesized from both shells using standard deacetylation technique. The synthesized chitosan, piroxicam and lactose were employed in preparing the drug loaded tablets by direct compression technique and subjected to characterization with the aid of Fourier Transform Infrared Spectroscopy (FTIR), Scanning Electron Spectroscopy (SEM) and optical microscopy. Finally, the drug release rate was investigated with in vitro drug dissolution test. The results of FTIR spectra confirmed that the biopolymer extract was chitosan and it also shows that there was no interaction between chitosan and the piroxicam. The morphological properties of the samples were found to be suitable for drug delivery. The applied load and composition of tablets influenced the drug release rates.