移植技术与研究

Treatment with Autologous Bone Marrow Mononuclear Cells in Patients with Non Reconstructable Critical Lower Limb Ischaemia

Abstract

Alaa Ismail, Hussein E, Sabbour A, Fawzy W, Anas Meshaal and Mounir R

Background and Aims: Treatment with autologous, bone marrow mononuclear stem cells has shown effects in patients with chronic limb ischaemia. The aim of the study was to test the potential effect of stem cell treatment in a strict defined group of patients with non reconstructable critical limb ischaemia (CLI).

Material: Twenty patients with non recontructable CLI of the lower extremities, who received medical treatment in the form of prostavasine.

Methods: Bone marrow cells were harvested from the patient’s iliac crest and, after separation, injected into the calf muscles of the affected leg. Outcome was evaluated by digital subtraction angiography (DSA), visual analogue scale (VAO) one patient was amputated two months after cell injection. Two patients reported relief of pain after four months.

Conclusion: This method seems to be a safe option for treating patients with non reconstructable CLI.