生物分析与生物医学杂志

Use of Hormonal Profile and Lipid Profile as an Index of Atherosclerosis in Menopausal and Perimenopausal Women at Lokoja International Market, Lokoja, Kogi State, Nigeria

Abstract

Emeje Paul Isaac*, Akubo Andrew Ojodale, Shedrack Egbunu Akor Zakari Usman Mbeng A. Mpame, and Clifford B. U

This was a cross – sectional study designed to evaluate hormonal and lipid profiles as indicators of menopause. 552 participants {138 (group A), 138 (group B), perimenopausal and menopausal {138 (menopausal woman designated group A), 138 (perimenopausal designated group B) (as test participants) and 276 (women of reproductive age designated as group C which served as control group} aged 18 and 64 years that were randomly recruited. One point sample collection was taken from each participant for determination of FSH, LH, PRL, TSH, Inh, Amh, E2, Prog, calcitonin, T.chol, Trig, HDL-C and LDL-C. FSH, LH, TSH were significantly high while PRL, Inh, Amh, E2, Prog and calcitonin were significantly lower in test participants when compared with control P< 0.05 respectively. T.chol, Trig, LDL-C were significantly higher while HDL-C was significantly lower in test participants when compared with control P< 0.05 respectively. The hormonal profile showed good correlations with lipid profile. The high sensitivities and positive predictive values of both hormonal and lipid profiles in groups A and B showed their predictive priorities in the diagnosis of menopause.