生物加工与生物技术杂志

Oleanolic acid, a pentacyclic triterpenoid, has gained significant attention in recent years due to its wide array of biological activities and therapeutic potential. Naturally occurring in various plant species, oleanolic acid is known for its anti-inflammatory, anticancer, hepatoprotective, antioxidant, and antiviral properties, making it a promising candidate for drug development. However, its relatively low bioavailability and the complexity of its chemical structure pose challenges for its widespread therapeutic use. To overcome these limitations, researchers have focused on developing novel derivatives of oleanolic acid through bioconversion and semi-synthesis techniques. These derivatives not only enhance the biological activities of the parent compound but also offer improved pharmacokinetic profiles, making them more suitable for clinical applications. Bioconversion and semi-synthesis are two complementary approaches that have emerged as effective strategies for modifying oleanolic acid and generating novel derivatives with enhanced biological properties. Bioconversion, involving the use of microorganisms or enzymes to modify the chemical structure of oleanolic acid, has become a valuable tool in the development of bioactive compounds.