生物医学与药物科学杂志

 Infertility has been one of the most common issue in the medical field, male infertility is more common and can be expressed in several forms, moreover a decrease in male reproductive hormones has been proven to affects spermatogenesis and due to this reason, pharmacognosy has been explored by researchers to provide alternatives for this problem. Symphonia globulifera, a plant widely distributed across the neotropic region and equatorial Africa has been used in traditional medicine due to its potency caused by the presence of potent metabolites.

Objectives: This study is carried out to evaluate the bioactive effect of globulixanthone  B on spermatogenesis and male infertility   

Method: This study was carried out using molecular docking to analyze the binding energy of the phytocompounds in symphonia globulifera on CYP11A, 3B-HSD, LHR and FSH-R which were furtherly visualized to calculate the chemical properties between the ligands and the receptors then the lead compound was register for druglikeness screening.

Results: This study has shown that Globulixanthone B is a lead compound with a significant binding energy with good binding affinity due to it hydrophobic interactions with the receptors. It has fufilled the five rules of druglikeness properties.

Conclusion:  This present work shows that Globulixanthone B is not only an highly efficacious compound but also a therapeutic alternative for boosting spermatogenesis and reducing