Ajit Kumar Saxena?Veena Singh?Aprajita?Aniket Kumar?Meenakshi Tiwari?Pritanjali Singh?Chandan K Singh ? Ramanuj K
??????β??1??TGF-βR1??????????????????????????????????????????????TGF-βR1???????????CNV????????DNA????????????????3D?????????????????????????????RT-PCR????????????DNA???Sanger?????CNV??????????????WT???TGF-βR1????????18.18??????Tm ??????? 90.70 ?? 91.0?????????p=0.24??95% ? CI ? 2.09-7.09 ???????????? SD=0.37?95% ? CI ? 0.337-0.906????????????????? TGA→TCA ? TGA→CCC????????????????????“?????”????/??????????????????? 3-D ??????????????????????????????????
Suresh Yadav?Sanjay Singh Chandel?Choudhary S?Veenita Yogi?Singh OP?Dinesh Kumar Saroj ? Goswami Brijesh
???????????????? (ICBT) ?????????? (2D) ?? X ???????????? 2D ??????? (3D) ????????????? (OAR) ?????????????????????????????? 3D ??????????????????
????????????? (Ca-Cx) ?????? (HDR) ICBT ???????? OAR ??????? (DVH)???????????? (CT) ??? ICBT ????????
???????????? 13 ???? Ir-192 HDR ???????? Ca-Cx ??? 39 ??? CT ???????? 13x3=39 CT????“A”??????? 3 ???? 7 Gy/???????????? (TPS) ???????????? 100% ?????????????? (HR-CTV) ??? 90% ??????????? OAR ?????????????????????????? HR-CTV D 90?HR-CTV D 100????“A”?? OAR ? D 2CC?
?????????? HR-CTV D 90?HR-CTV D 100????“A”?????????? 100.82 Gy?SD?± 6.08??70.95 Gy?SD?± 2.76?? 79.46 Gy?SD?± 0.66??????????????? D 2CC??????? 68.89 Gy?SD?± 8.76??63.74 Gy?SD?± 3.82?? 73.20 Gy?SD?± 3.04??
????????????????3D-CT ????? Ca-Cx ICBT ????????????
??·??????????·??????·?????????·???????·?·??????·????·????
????????????????????????????????? C ??????????????????????????????????????????????????????????????????????????????????????
?????? 2014 ? 9 ????????????????????????????????????????????????????????????-68 ??????????????? - ??????? (68Ga PET-CT) ????? 2018 ? 12 ??
?????????????????????????????????????????????????????????????????
???????????????????????????????????????????????????????????????????
??·? (Inna Chen)???·????·?? (Benny Vittrup Jensen)????·???·??? (Stig Egil Bojesen)??????·????·??? (Astrid Zedlitz Johansen)????·???·??? (Nicolai Aagaard Schultz)????·???·?? (Carsten Palnæs Hansen)??·???·???? (Jane Preuss Hasselby)????·???·??? (Niels Henrik Hollander)???·???·????·?? (Mette Hedager Bredahl Nissen)???·???·????? (Jon Kroll Bjerregaard)???·?? (Per Pfeiffer)???·??·???? (Mette Karen Yilmaz)????·??·???? (Louise Skau Rasmussen) ????·???·???????·???????·???·??????·????·???
?????? (PC) ???????????????????????????? PC ?????? 25% ? PC ???????????????????????????? PC ????????????????????????? (1) ???????????????? PC ???????????????(2) ??????/? (3) ???????????????????
????????????????????????? PC ??????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????? 19-9?C ???????????????????????????????????????????????????????????2019?7?7????2141????5156????
????????????????????????? (DNA)???????? (SNP)????? (RNA)?microRNA????????????????????????????
????????????????????????????????? PC ????????????????????
????? ClinicalTrials.gov ID?NCT03311776???????????????? 2017 ? 10 ? 6 ??
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