Shravan K. Putta
?????????????????????JCST????????????????????????????????????????????????????????????????????????????????????????? 11 ???????? 2019 ?????????
Amit kumar?Sanjay Kumar?Rishi K. Singh?Praveen K. Verma?Sandeep Kumar?Munendra S. Tomar ? Arbind Acharya
?????? 2019 (COVID-19) ???????????? 2 (SARS-CoV-2) ?????????????????????COVID-19 ??????????? 2019 ? 12 ?????????????????????????? COVID 19????????????????????????????????????????????????????????????????????????????????????????????????????? COVID-19 ?????????????????????????????????????????? COVID-19 ??????????????????????????????????
Mira Canaan?Eman El-Sheikh?Ramy R. Ghali?Nada E. Eldin?Gehan Hamdy ? Wesam El-Ghamry
??????????????????????????????????????? PLR ? MPM ????????
??????????? 2013 ? 1 ?? 2017 ? 12 ???????????????????? MPM ??? 400 ????? 110 ????????? CBC ??? PLR?
??? 110 ???????? 28 ? 70 ??????? 5?6??????? 85%?III ?? IV ???? 48.2% ? 35.5%??? PFS ? OS ??? 6.9 ??? 11.9 ???????? 177.9?? PLR ????? PFS ??? PLR ???7.97 vs. 6.63???p=0.039????? PLR ???? PLR ????? OS ??? 15.07 vs. 10.4 ???P ?=0.063?61.8% ?????????????38.2% ??????/?????????????????????????? 47%?29%?23% ? 0.9% ???? SD?PR?PD ? CR?????/???????/?????????? PFS ? OS ???????p=0.53??????/???????? PLR ??? PLR ???? OS ??? 17.5 ??? 10.5 ???P=0.108???? PFS ??? 7.7 ??? 5.03 ???P=0.034??????-???????? PLR ??? PLR ???? OS ??? 15.07 ??? 8.2 ???P=0.264???? PFS ??? 8.07 ??? 8.2 ???P=0.332??
??? PLR??????????????PLR???PLR?PFS????????????PLR?PFS??????????
????·??????????·????????·??-???
??????????????????????? (CLL) ??????????? B ???????????? p-53 ?????
????? ELISA ?????? 20 ???? CLL ???? p-53 ?????????
???? II-III/IV ?????????
????? B ? CLL ???? p-53 ?????????? 15%?20
????? 17 ?? p-53 ??????? 16.76 μg/dl?CV=0.5%????? p=0.034???
?????p-53 ?????????????????1-2 ?? 15% ± 2??
3-4 ?? 100%?
???ELISA????????????CLL??????????????p-53???????
???????????
??????????CLL???????????????
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