Zohra Tumur?Carlos Guerra?Peter Yanni?Ahmad Eltejaye?Christi Waer?Tursun Alkam ? Bradley S Henson
??????????????????????????????????????????????? (RA) ????????????????????????????????????????????????????????? RA ???????? (EGF) ???????? HNSCC ??????????????? (ROS) ?????????????
??????? WST-1 ?????????????????? CM-H2DCFDA ROS ????? RA ??????? HNSCC ????UM-SCC-6 ? UM-SCC-10B??????????????? (ROS) ????????????? RA ? EGF ????????????????
??? RA ??? HNSCC ??????????????? ROS ??????RA ???? EGF ??? EGFR ????? 992 ? 845 ??????????? 3-?? Akt (PI3K/Akt) ?????????? ERK (MAPK/ ERK) ?????
?????????? RA ? HNSCC ???????????????????????????? RA ??????????? EGF ??? PI3K/Akt ?????????? RA ?????? HNSCC ??????
Ahmad A Omran?Esmat A Elsharkawy?Ayman G Ghobrial?Hosny B Hamed?Waleed M Abd el Hameed?Nagwa I Okaily ? Abdel-Azeem M. El-Marazy
??????????????? (ALL) ??????????????????????????????????? CD44 ?????????????????????CD44v6 ? CD44 ????????????????????????????????????????????????????????? CD44 ? CD44v6 ???????? ALL ?????????????????
??????????? 57 ???????? 1 ??? 40 ?????????????????????????? 2 ??? 17 ???????????????????????????????????????????????????????????????CBC?Leishman ?????????LDH???????????????????????????????? BM/PB ?????????????????????????????????????????? RTPCR ??????? CD44 ? CD44v6 mRNA ???
??? I?CD44??????II??P=0.001???CD44v6?I?II???????????CD44%?LDH???????????????????????r=0.64?P=0.001&r=0.62?P=0.001&r=0.92?P=0.001???CD44%??????HB????????????????r=-0.93?P=0.001&r=-0.92?P=0.001????????CD44%?????????????/??????????????????? CD44v6 ??????????????????P=0.1??? ALL ??? CD44 v6?HB ???????????????LDH ??? BM ???????????
??? CD44??CD44v6???????ALL?????????????CD44????????????
????·?·?????????·?????????·??????·????????·????????·???·?·????????·???
?????????????????????????????????????????????????????????????????????????????????????????????????? (BMMC) ?????????????
???????????????????? BMMC?MTT ????????????? BMMC ??????????????????????????? 20 ????????????????????????? (CT) ?????????? 18.5 cm2???? 16-24 cm2??16 ???????????????????????4 ??????????? BMMC ???????????????????????????? (MSTS) ????????????????????????????
????????????????? 90% ? BMMC ????????????????????????? BMMC ???????????????????MSTS ?????????????? 82%????????????? 60%???????????????????????????
???????????????????????????? BMMCs ???????????????????????????????????????????????
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