?·???·???
??????? DNA ??? 16k ??????????????? C+A ? T+G ????????????????????????????????????????????????????????????????? DNA ????????“????”??????????????????? 250 ?????????????????????????????????????????????????????????????a????250 ?????????????? DNA ?? 1 ????b???????????????????? DNA ???“??????”??c?“???”????? 250 ??????????? DNA ?????????
Ahmed WA?El-Semary NA?Abd El-Hameed OM?El Tawill G ? Ibrahim DM
????????????????????????????????????????????????????????????????????????????? 23S rDNA ????????????????????????????? Plectonema ?????????????????????????? (HepG2) ???????? (Cyanothece sp.) ? (Plectonema terebrans) ?????????????????????????????IC50 ???? 13.3% ? 8.3%???????????????? caspase3 ???????????6.6%?????Cyanothece sp.???Plectonema terebrans?????????????? 66.7% ? 57.4%?????????????? Cyanothece sp ?????? G0/G1 ? G2/M ????????? 52.8% ? 0.33%??2n ???????46.4%???? Plectonema terebrans ????????????G0/G1 ??? 63.3%?G2/M ??? 0.3%?2n ??? 35.6%??G0/G1 ? G2/M ???????????? 7.38% ? 0.13%??2n ????????91.8%???????????????? Caspase-3 ???????? 13.3% ????????? 0.397 ± SD 0.02???????????? Caspase-3 ???????? 4% ????????? 0.402 ± SD 0.002????????? (0.157 ± SD 0.05 nM/mL) ???? (p<0.05)??????????????????????????
??? G?????? S????? A?????? A??? AM???? A
???? III ?????????????? CD30 ????? Brentuximab Vedotin (BV) ???????????????????????/?????????????? (cALCL) ????????????????????????????????????????????????????????????? 78 ?????? cALCL ??????????????????? BV ????????????????????
Shereen El-Shorbag??y?Rasha Haggag?Huda F Ebian?Hany A Labi?Ola A Harb
????????????? D?Vit D???????????????????????????????????
?????????????????????????????? 168 ?????????????????? 25 (OH) ??? D ???????? D ??????????<10 ng/ml????10 ng/ml ? 30 ng/ml????>30 ng/ml???????????????????????? D ??????????
????????51.5?26-77???13.1%??????????25?OH?Vit D??????20?5-98?ng/ml?36.9%??????32.1%??????31%????????25?OH?VitD????????BMI??????????P=0.00???25?OH?Vit D?????????????????????KI 67????????????????p=0.01?p=0.011?p=0.002?p=0.001???????????25?OH????D???????p=0.01????????????????? D ??? 3 ???????????? (DFS) ???????? (p=0.13)?????????????? D ???????? PFS (p=0.98)?3 ???????? D ??????????????? OS ??? 45.8 ???39.7 ??? 39 ?? (p=0.047)????????????BMI??????????????? D ?????? OS???? p=0.014?p=0.002?p=0.002?p<0.0001 ? p=0.047??????????????BMI??????? D ????????? OS ????????? p=0.01?0.001?p<0.0001 ? p=0.022??
?????25(OH)Vit D????????????????
???? A?????? A?Bitsadze V???? N?????? M
??????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????
Nesrine Benkafadar?Carolanne Coyat?Ruth Lloyd1?Jean-Luc Puel?Jing Wang
???????????????????????????????????????????????????????????????????????????? p53 ???????????????????????????????????????????????????
Khalid Lmezguidi?Abdelatif Janane?Fouad Hajji?Omar Jendouzi?Mohamed Alami?Ahmed Ameur?Mohamed Abbar
??????????????????????????????????????????????????????????????????????????????????? (MIBT) ????????
?????????????? 1990 ?? 2014 ???????????????????? MIBC ??????????????? 308 ???????????? 218 ??70.77%??? 1 ??????? MIBC?90 ??29.22%??? 2 ??????? MIBC??????????? 2 ????????TUR ?????????????T/N??????????????????? Kaplan-Meier ??????????? Cox ??????????????????????
???? 2 ????????????????? 32 ???? 1 ????? 2?3 ? 5 ???????????? 77%?63% ? 51%?? 2 ????? 2?3 ? 5 ???????????? 59%?49% ? 32%?p < 0.05???? pN ???? 1 ??? pN0 ??? 2?3 ? 5 ??????? 75%?62% ? 53%?? 2 ??? pN0 ??? 2?3 ? 5 ??????? 61%?49% ? 37%?p < 0.05?????????????????????? pT ??????????????????????
?????????????? MIBC ??????? MIBC ?????????? RC ?????????????? MIBC ???????????
Tetsuzo Tauchi*?Seiichi Okabe?Seiichiro Katagiri?Yuko Tanaka?Kaoru Tohyama ? Kazuma Ohyashiki
???????????? (MDS) ??????????????????????????????????????? (AML)??????? MDS ???????????????????????? AML ??????????? MDS ??????????? MDS ?????????Glasdegib ?????????? Hedgehog ?????????????? Smoothened (SMO) ????????? I ?????? Glasdegib ????????????????????????????????????????????? Glasdegib ???? MDS ?? iPS ?? (iPSC) ??????????
?????????? 5 ?????????????? MDS ????????????? iPSC???????????? glasdegib ? MDS ??? iPSC ??? NOD/SCID ????????????????????? Hedgehog ?????????????NOD/SCID ?????? MDS-iPSC???? glasdegib ???
????????????????????glasdegib ????? NOD/SCID ????? MDS ?? iPSC ???????????NOD/SCID ????? MDS-iPSC????? 21 ?? glasdegib ?? 7 ????????? CD34+CD38-?????????? Hedgehog ????????????? MSD-L ??? 5-????? glasdegib ???? 72 ???Glasdegib ????? PARP??? caspase-3?p21 ???????? c-Myc ????
??????????????glasdegib ?????????? MDS ???????????? glasdegib ????????????? MDS???????????????? MDS ?????????
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