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DNA ???????????????????????????????????????????????????????????????????????????????? DNA ??????????????????? DNA ???????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????
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??????Salvia bowleyana?S. splendens?S. officinalis??????????????????????Illumina Hiseq 2500???Salvia bowleyana?S. splendens?S. officinalis?????????????S. bowleyana?S. splendens?S. officinalis????????????151,387?150,604?151,163?????IR????ndhB?rpl2?rpl23?rps7?rps12?ycf2?????S . bowleyana?S. splendens?S. officinalis???????????29????????35??????????24??????????47?49?40???????? 23 ??????????? rps16-trnQ-UUG?trnL-UAA-trnF-GAA ? trnM-CAU-atpE ?????????? (IGS) ????????????????? 91 ?????????????? IGS ?? (ycf3-trnS-GGA ? trnG-GCC-trnM-CAU) ???????????????????? K2p ?????????? 23 ?????????????????????? DNA ???????????????????????????????????????????????????????????????????????????????
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?? AFM????????????????????????????? (IRRAS) ?? DNA ???? (AFM) ????????????????????????? DNA ??????????? DNA ????????????????????? DNA ??????????????????????????????????????????? DNA/????????????????? DNA ??????????????????? DNA ???AFM ?????????????????????? DNA ??????????????????????????????????? DNA/??????????????? DNA ?????????????????????????????????????????????????????
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?????? (CR) ????????????????????????????????????/I ???????? (KIR/HLA-I) ????????????? (NK) ????????????????????????? CR ???????????????????????? (PCR-SSO) ???? 513 ?????? KIR ? HLA ??????????????? CR (n=35) ??????? (NCR=478) ?? KIR???????? C (HLA-C) ????KIR ????? KIR/HLA ????????????? (rKIR2DS2+ ? rKIR2DS3+) ????? KIR (aKIR) ????? CR ? NCR ? (p=0.013 ? p=0.038)??? rKIR2DL2+ ????? KIR (iKIR) ??????? CR ????? (9.1% ? 3.7%?p=0.020)?KIR2DL3 ????? CR (13.1% ? 5.2%?p=0.008)?? NCR ?????? HLA-I ?? (MM) ???? CR??? (d) HLA-C2 ?? (dC2−) ??????????????? CR (13.1% ? 5.6%?p=0.018)?? rKIR2DL3+/dC1−(p=0.015)?rKIR2DS4/dC1−(p=0.014) ? rKIR2DL3+/rKIR2DS4+/dC1−(p=0.006) ???? CR ??????
??? 5-10 ??rKIR2DS1+rKIR2DS4+/dC1− ??????????????????? rKIR/dHLA-C ??? aKIR ????? CR ? KIR2DS1+/C1-????????? KIR2DS4+/C1-??????????????
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?????????????????????? (TBM) ???????????????????????????????????????????????????????????????????????????? 22 ? 43 ??????????????????? 20 ?????????? (CBCT) ???????????????????????????????????????????????????????????? Analyze Direct 14.0 ???? CBCT ??? DICOM ???????????????????????????????????? TBM ???????? Pearson ???????????????????????????????????? (p>0.05)?? Tb. N (r=−0.489)?BS/television (r=−0.527) ????? (p=0.029 ? p=0.017???) ????????????????? Tb. N ? BS/television ??????????????????????????????????????????????????????????????????????????????????????