生药学与天然产物杂志

The stem-bark of Sterculla oblonga, which is a rich lignocellulosic material, was analysed using GC-MS chromatography in other to identify the bioactive compounds present in the plant and deduce its possible therapeutic potentials. The pulverized plant sample was extracted by maceration for 48 hours using ethanol solvent, after solvent recovery, the crude extract was used for the GC-MS analysis. Results revealed the presence of 12 bioactive compounds namely: 1-(Butylsulfanyl)-2-ethoxyethane 4-methoxyphenol (mequinol), 2,6-dimethoxy-phenol (Syringol), 3,4,5-Trimethoxyphenol, 4,4,5,6-Tetramethyltetrahydro-1,3-oxazin-2-thione, n-Hexadecanoic acid (Palmitic acid), 1-Docosene, 14-methyl-8- hexadecen-1-ol, 1,19-Eicosadiene, Z-10-Tetradecen-1-ol acetate, 1-Nonadecene and Oleic Acid. These chemicals were further grouped into 5 viz organo-sulphur (2%), phenols (24%), alkaloids (2%), fatty acids/esters (22.18%) and hydrocarbons (8.66%). Because of the high percentage of phenolic compounds present, the ethanolic extract of stem-bark of S. oblonga could find useful therapeutic applications as antimicrobial, anticancer, anti-oxidant and anti-diabetic agents.

Negundo plant, also named as five leaves chaste tree belongs to the family lamiaceae, an evergreen medicinal plant belongs to the nativity of in china, japan and India. Parts of leaves, roots, seeds and flowers were having many beneficial activities with pungent, bitter, and astringent tastes consists of enormous phytochemical constituents such as alkaloids, steroids, flavonoids, glycosides, volatile oils, lignans, iridoids, terpenes, and steroids for multi-purpose therapies including analgesic, anti-inflammation, digestion, respiratory system, menopausal phases. The plant is typically known for its role in the modulation of various cellular events in the human body like apoptosis, cell cycle, and motility of sperms, polycystic ovary disease, and menstrual cycle as it stimulates and plays a key role in the treatment of certain conditions. Its extractions using leaves were used for many home remedies like to cure cough, asthma, wound, ulcer, joint pain and swelling. Many bioactive compounds obtained from this plant have been commercialized and are under investigation currently. In this review, we highlighted and presented up-to-date information about this plant and made a detailed study about its phytochemical constituents, microscopic studies, general uses, adverse effects, marketed preparations, and beneficial effects.