Masa-Aki Shibata, Yoshinobu Matoba, Hideki Tosa and Munekazu Iinuma
The pericarp of the mangosteen fruit, Garcinia mangostana Linn, has a long history of use as a medicinal plant in Southeast Asia. The actions of mangosteen extracts have been scientifically supported and it has become a popular natural health-promoting dietary supplement. Mangosteen extracts, particularly α-mangostin, induced apoptosis via the mitochondrial pathway, cell cycle arrest by p21cip1 induction and Akt dephsophorylation in mammary cancer cells; these anti-proliferative effects are associated in vivo with suppression of tumor growth and metastasis in mouse mammary cancer models. Such preclinical evidence suggests that mangosteen extracts have potential chemotherapeutic and/or chemopreventive uses
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