遗传学和 DNA 研究杂志

Type A gamma-butyric acid (GABAA) receptor is the main inhibitory neurotransmitter receptor family in the brain. Previous studies including those by us have associated GABAA receptor structural and functional variations with neuropsychiatric disorders such as schizophrenia.

Statement of the Problem: G-protein coupled receptors (GPCRs), an essential molecular signaling device to connect extracellular stimulus and intracellular response, are currently one of the major targets for therapeutic drugs

In 2008, there were an expected 110 million common STIs among ladies and men in the United States. Of these, over 20% of diseases (22.1 million) were among ladies and men matured 15 to 24 years. In 30 unique microscopic organisms, infections, and parasites prompt more noteworthy than 1 million sexually transmitted contaminations every day.

The uptake of exogenous solutes is mediated by transport systems embedded in the plasma membrane and drive active transport even at μM to nM solute concentrations. In many of these systems a periplasmic Solute-Binding Protein (SBP) is utilized to bind their cognate ligands with high affinity and deliver them to the membrane bound translocator subunits.

Details of protein folding mechanism are still unknown. The solution to this problem is useful for elucidating the mechanism and treatment of diseases caused by misfolding.