Khanh vinh quoc Luong and Lan Thi Hoang Nguyen
The relationship between supplemental thiamine and Wilson’s disease has been the focus of recent investigation;and supplemental thiamine has been reported to modulate Wilson’s disease. Genetic studies have helped identify a number of factors that link thiamine to Wilson’s disease, including transcription factor p53, Bcl-2, caspase-2, heme oxygenase-1, and apolipo protein E. Thiamine has also been implicated in Wilson’s disease through its effects on serotonin, reactive oxygen species, and nitric oxide synthase. Therefore, further investigations of thiamine in Wilson’s disease are needed to clarify this relationship.
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