皮肤病学和皮肤病杂志

Malignant Blue Nevus Arising in a Congenital Cellular Blue Nevus in a Young Woman: Case Report and Review of Literature

Abstract

Mirna Situm, Zlatko Marusic, Zeljana Bolanca and Marija Buljan

Malignant blue nevus is a term related to melanoma arising in association with or that resembles blue nevus. Such lesions are extremely rare with occasional reports and a few small series of cases described in the literature; therefore, the biology and prognosis of such tumors is not well clarified. Due to lack of strictly defined histopathological criteria, such lesions may present a significant diagnostic challenge. We are presenting a case of a malignant blue nevus arising in a congenital cellular blue nevus, presenting as a slowly progressing and asymptomatic pigmented lesion on the buttock of a 21-year-old woman. Histopathological analysis showed presence of a cellular blue nevus as well as features characteristic for malignant blue nevus. The definitive diagnosis was reached only at the histopathological and immunohistochemical examination. The histological features and clinical course in our patient are also discussed in context and the review of the previous related literature.