John Hebrew*
Lipotoxicity is a condition characterized by the harmful effects of excessive lipids on cellular health. It plays a significant role in the development of metabolic disorders such as obesity, type 2 diabetes, Non-Alcoholic Fatty Liver Disease (NAFLD), and cardiovascular complications. The accumulation of lipids, particularly Free Fatty Acids (FFAs), disrupts cellular function through mechanisms such as impaired insulin signalling, Endoplasmic Reticulum (ER) stress, oxidative stress, and mitochondrial dysfunction. This article provides an in-depth exploration of lipotoxicity, including its mechanisms, consequences, interventions, and future directions. Understanding lipotoxicity is crucial for developing effective strategies to prevent and manage its detrimental effects on human health.
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