Chin-Yuh Yang,Ming-Chi Shih,Yuh-Ling Lin*
The aim of this study was to verify the beneficial hypolipidemic effect of commercial soya bean fermentation broth with saponins (SFBS) in hamsters with hyperlipidemia induced by 0.2% cholesterol (high-fat [HF] diet). Male Golden Syrian hamsters were randomly divided into two groups: control (standard diet, n=8) and experimental (HF diet, n=32). After one-week acclimatization, all animals in the experimental group fed with the HF diet for 8 weeks. The 32 hyperlipidemic hamsters were divided into four groups (n=8 per group), and with 3 mg/day/kg ezetimibe or 350 mg/kg/day (SAP350) or 700 mg/kg/day (SAP700) SFBS by oral gavage over the 8 weeks or HF diet only. After 8 weeks, the SFBS significantly decreased serum total cholesterol and low-density lipoprotein cholesterol concentrations by about 20% (SAP350) and 42% (SAP700), respectively, compared with the HF diet without SFBS or with ezetimibe (3 mg/kg/day). We propose that the SFBS might be reducing the serum cholesterol level by increasing fecal excretion of cholesterol and bile acids by about 20% and 35%, respectively. The results of biochemical analysis of kidney and liver function in the experimental animals suggested that there were no side effects of SFBS feeding for 8 weeks.
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